While grieving for the deceased sister that she never really knew, Agnes Evans finds her sister Tilly’s Dungeons and Dragons notebook. In an attempt to understand who her sister was, Agnes enlists a dungeon master Chuck to decipher the notebook and it’s mind flayers, displacer beasts, and flesh-eating cheerleaders. She Kills Monsters, which is set in the Midwest pop culture of the ‘90s, jumps back and forth from the fantasy battles Tilly created, and real-world demons that Agnes has yet to confront.